genglob magazine


magazine by for generics, medicines and alternative treatments like ayurveda and traditional chinese

Treat Cancer Smarter With Molecular Profiling

Five words or lessMore than 1.5 million people in the United States will be diagnosed with cancer this year.
Of the many critical decisions they will have to make, none is more important than the type of treatment that will be used to fight their cancer — especially when patient response rates aren’t very promising.

First line or standard therapies for cancer fail, on average, at least 70 percent of the time, and, when they do, studies show that as few as 5 percent of cancer patients respond to the second standard treatment plan they are given.
However, a recent study in the Journal of Clinical Oncology showed that when 
molecular profiling was used to guide the selection of cancer therapy, a drug known to target the specific biomarkers of a tumor was found in 98 percent of advanced cancer patients studied. Read the rest of this entry »


Experimental Cancer Treatment Offers Hope

Now we turn to what is being hailed as a breakthrough in the fight against cancer. A small group of pioneers sending a big ray of hope. An experimental treatment that appears to stop cancer cells in their tracks in some people. And abc’s dr. Rich about bard besser tells us about the big news today. Reporter: David asponte was out of options.

He was being treated for acute lymphocytic leukemia, a rare and often fatal disease in adults. When chemotherapy failed, doctors turned to an experimental treatment. Robin roberts went to visit him last december.

I think I am on the right road, I think I am on the right road. Reporter: Doctors took out millions of david’s disease-fighting white blood cells, then used a retrovirus, which is great at getting into human immune systems to change those cells to targeted cancer fighters. David’s cells went back in and destroyed the cancer like a living drug.

The first patient to have similar experimental treatment was 7-year-old emma whitehead who went through the procedure last year and now is in complete remission. She has a ton of energy. She’s doing wonderful right now. Read the rest of this entry »


Stem cells transplantation technique has high potential as a novel therapeutic strategy for ED

Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction (ED), conclude the authors of a study presented at the 28th Annual EAU Congress later this week.

The study was conducted by a group of Korean scientists and will be awarded 3rd prize for best abstract in non-oncology research on the opening day of the congress.

During their investigation, the group aimed to examine the differentiation of human mesenchymal stem cells cultivated on the surface of nanofibrous meshes (nano-hMSCs) into neuron-like cells and repair of erectile dysfunction using their transplantation around the injured cavernous nerve (CN) of rats.

“The objectives of the study reflect a very pertinent need in today’s urology practice,” said the lead author of the investigation Prof. Y.S. Song of Soonchunhyang University School of Medicine in South Korea. “Post-prostatectomy erectile dysfunction results from injury to the cavernous nerve that provides the autonomic input to erectile tissue. It is a common complication after radical prostatectomy which decreases the patient’s quality of life”. Read the rest of this entry »


Natco Pharma awarded the compulsory licence to manufacture Bayer’s cancer drug Nexavar

Natco Pharma is back in limelight after the Indian Patents Appellate Board upheld the decision of awarding compulsory license to the drug firm to manufacture Bayer’s cancer drug Nexavar at a significantly reduced price.

The Hyderabad-based drug company is engaged in formulations, active pharmaceutical ingredients ( APIs) and owns a retail pharmacy business in the US. It earns majority of its revenues from oncology drugs. Following the Indian Patent office awarding compulsory license to the company, it has been selling the generic version of Bayer’s drug Nexavar, meant for treating a rare liver and kidney cancer, since April last year. In the months from April to December last year, the company sold the drug worth Rs 14 crore and expects the revenues from this product to range between Rs 15 and 20 crore in the coming years. While the company does not earned significantly from the drug, it achieved the breakthrough of winning a compulsory license for manufacturing the generic version of a life-saving drug – opening inroads for cheaper drugs in the country. Read the rest of this entry »


Sorafenib (Nexavar )

This chemotherapy and cancer drugs article is about Sorafenib (Nexavar) which is a treatment for advanced kidney cancer.  It is a type of biological therapy, called a protein tyrosine kinase inhibitor (TKI). Tyrosine kinase is a protein which acts as a chemical messenger that encourages cancer cells to grow.  Sorafenib blocks these proteins and thus stops the cancer creating blood vessels (anti-angiogenesis).  It is currently being researched for use with liver cancer.Research published in the NCI Cancer Bulletin, in 2007 showed that sorafenib also  improves the survival of patients with advanced liver cancer. It is taken in tablet form.

Side effects are generally mild and can include:  diarrhoea, soreness and redness in the palm and soles, fatigue, skin rashes, hair thinning, nausea, bruising and bleeding, raised blood pressure, increased risk of infection, loss of appetite, constipation, aches and pains.


India Appeals Body Rejects Bayer’s Plea on Nexavar

India’s patent appeals body Monday rejected Bayer AG’s plea to stop a local company from manufacturing and selling a generic version of its cancer drug Nexavar, a ruling that has wider implications for multinational drug makers operating in the South Asian nation.

The German company last year approached the Intellectual Property Appellate Board after the local patent authority granted a “compulsory license” to Natco Pharma manufacture a generic version of the drug.

The Indian Controller General of Patents, Designs and Trademarks allowed Natco to make copies of the liver- and kidney-cancer drug on the grounds that Nexavar was too expensive for most people in India. The license allowed Natco to sell a generic version at less than one-30th of Bayer’s price. Read the rest of this entry »


Indian court to rule on generic drug industry

From Africa’s crowded AIDS clinics to the malarial jungles of Southeast Asia, the lives of millions of ill people in the developing world are hanging in the balance ahead of a legal ruling that will determine whether India’s drug companies can continue to provide cheap versions of many life-saving medicines.

The case — involving Swiss drug maker Novartis AG’s cancer drug Glivec — pits aid groups that argue India plays a vital role as the pharmacy to the poor against drug companies that insist they need strong patents to make drug development profitable. A ruling by India’s Supreme Court is expected in early 2013. Read the rest of this entry »


Late Effects and Healthy Living: Lessons for Childhood Cancer Survivors

Once childhood cancer patients have been declared cancer-free, most are not completely out of the woods. More than 60 percent of childhood cancer survivors experience late effects of cancer treatment resulting in chronic conditions. The New England Journal of Medicine says nearly half of all late effects are severe, life threatening or disabling.

Although two-thirds of all childhood cancer survivors develop late effects—including breast cancer, heart disease, learning disabilities, infertility and hearing loss—few get adequate follow-up care.

“Most of them don’t know their risks for medical late effects, which puts them in a very precarious position in terms of maintaining their health,” says Nancy Keene, a parent of a survivor of childhood leukemia, and author of topical books including “Childhood Cancer Survivors: A Practical Guide to Your Future.” Read the rest of this entry »


Three Ways to Reduce Exposure to Cell Phone Radiation

Five words or less

The debate about radiation exposure from cell phone use still doesn’t have a conclusive answer, but the World Health Organization (WHO) classified cell phone radiation as a “potential carcinogen” alongside other hazards like lead, engine exhaust and chloroform. That means prolonged cell phone use can possibly increase the risk of specific types of brain cancer and tumor growth, according to WHO.
Although international research, such as the noted Interphone study conducted by the International Agency for Research on Cancer, continues to be somewhat contradictory, experts agree consumers have reason for concern, particularly heavy users and youth. Read the rest of this entry »