genglob magazine


magazine by for generics, medicines and alternative treatments like ayurveda and traditional chinese

Sorafenib (Nexavar )

This chemotherapy and cancer drugs article is about Sorafenib (Nexavar) which is a treatment for advanced kidney cancer.  It is a type of biological therapy, called a protein tyrosine kinase inhibitor (TKI). Tyrosine kinase is a protein which acts as a chemical messenger that encourages cancer cells to grow.  Sorafenib blocks these proteins and thus stops the cancer creating blood vessels (anti-angiogenesis).  It is currently being researched for use with liver cancer.Research published in the NCI Cancer Bulletin, in 2007 showed that sorafenib also  improves the survival of patients with advanced liver cancer. It is taken in tablet form.

Side effects are generally mild and can include:  diarrhoea, soreness and redness in the palm and soles, fatigue, skin rashes, hair thinning, nausea, bruising and bleeding, raised blood pressure, increased risk of infection, loss of appetite, constipation, aches and pains.




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